Rates
Please submit a Service Request for consultation with CTRC to receive a custom cost estimate for your project. Contact us as early as possible during project development and funding application preparation.
The CTSI asks that investigators include the total costs of CTRC services in their budgets for all grants and contracts. Rates are subject to change each fiscal year (starting July 1). We suggest budgeting a 5% annual escalation for services planned in future fiscal years.
*External Investigators from Utah CTSI Hub Partner Sites should contact the CTRC with information about project funding source to receive a customized quote.
**The Utah CTSI subsidizes some rates for internally funded studies and those funded by study sponsors EXCEPT Commercial/Industry/Industry-Sponsored Non-Profit sponsors. Documentation of sponsor type must be demonstrated to the CTRC to receive the internal subsidized rates.
Consultation Services
| Service | Description | Internal Rate | External Rate* |
| Lab Director (Per hour) | One-on-one consultation with the CTRC Lab Director to discuss study design, sample processing strategies, feasibility, or technical guidance for your research project. Billed per hour. | $147.00 | $226.38 |
| Staff Rate (Per hour) | Consultation with experienced CTRC laboratory staff for technical questions, protocol review, or project planning support. Billed per hour. | $74.00 | $113.96 |
Nucleic Acid Isolation (DNA and RNA) Services
| Service | Description | Internal Rate | External Rate* |
| DNA extraction blood (up to 10mL per sample) | Genomic DNA isolated from whole blood samples up to 10 ml. The CTRC selects the most appropriate extraction kit based on sample quality and downstream application requirements. Investigators may request a specific kit if their experimental needs require it. | $42.98 | $66.19 |
| DNA extraction saliva | Genomic DNA extracted from saliva samples. The CTRC selects the optimal extraction method for yield and purity based on sample type. Investigators with kit-specific requirements should indicate this at the time of submission. | $49.45 | $76.15 |
| DNA extraction buffy coat | Genomic DNA isolated from the buffy coat layer of centrifuged blood, enriching for leukocytes to maximize yield. The extraction kit is selected by CTRC staff unless a specific kit is required by the investigator's protocol. | $42.98 | $66.19 |
| DNA extraction soft tissue/other | Genomic DNA extracted from soft tissue or non-standard sample types. The CTRC determines the most suitable extraction method. Investigators requiring a specific kit should specify this at the time of submission. Please contact the lab to confirm sample compatibility prior to submission. | $49.26 | $75.86 |
| DNA extraction swab | Genomic DNA isolated from buccal or other biological swabs. CTRC staff select the extraction method best suited for low-input or variable-quality samples unless a specific kit is requested by the investigator. | $28.49 | $43.88 |
| Free-circulating DNA | Cell-free circulating DNA (cfDNA) isolated from plasma or serum using the KingFisher automated nucleic acid extraction system. Suitable for liquid biopsy and other low-input applications. Investigator-specified kits can be accommodated upon request. | $38.60 | $59.44 |
| DNA extraction cell culture lines (single well of 6 plate or smaller) | Genomic DNA extracted from adherent or suspension cell culture lines grown in a single well of a 6-well plate or smaller. The CTRC selects the extraction kit unless a specific method is required for downstream assays. | $27.01 | $41.60 |
| RNA extraction using PAXgene Blood RNA Kit (up to 8ml per sample) | Total RNA isolated from whole blood collected in PAXgene Blood RNA Tubes (up to 8 ml). The PAXgene system stabilizes RNA at the time of collection, preserving high-integrity RNA suitable for gene expression and transcriptomic analysis. | $71.28 | $109.77 |
| RNA extraction using Tempus Blood RNA Kit (up to 8ml per sample) | Total RNA extracted from whole blood collected in Tempus Blood RNA Tubes (up to 8 ml). The Tempus system stabilizes RNA at the time of collection, providing high-quality RNA for downstream transcriptomic applications. | $43.53 | $67.03 |
| RNA extraction soft tissue/other | Total RNA isolated from soft tissue or non-standard sample types. The CTRC determines the most suitable extraction method. Investigators requiring a specific kit should specify this at the time of submission. Please contact the lab to confirm sample compatibility prior to submission. | $49.16 | $75.71 |
| RNA extraction cell culture lines (single well of 6-well plate or smaller) | Total RNA extracted from cell culture lines grown in a single well of a 6-well plate or smaller format, optimized for yield and RNA integrity. The CTRC selects the extraction kit unless a specific method is required for downstream assays. | $30.66 | $47.22 |
| Rnase Treatment per 8mls of blood | Enzymatic RNase treatment to remove residual RNA contamination from DNA preparations derived from up to 8 ml of blood, yielding high-purity genomic DNA for downstream applications. | $1.70 | $2.62 |
| Qubit measurements per sample | Fluorometric quantification of DNA or RNA concentration per sample using the Qubit platform, providing accurate and sensitive measurements for low-concentration or dilute specimens. | $3.45 | $5.31 |
| Each Extra Aliquot | Additional aliquots of extracted nucleic acid prepared and labeled for long-term storage or distribution. Aliquots must be requested at the time of sample submission. Each additional aliquot beyond the standard deliverable is charged individually. | $1.15 | $1.77 |
| Hourly Rate | Services billed at hourly rate. For non-standard work requests, our+B16:B23 team tracks time daily using JIRA. Hours are calculated at the end of each month and invoiced at the beginning of the following month. | $74.00 | $113.96 |
Blood and Cell Culture Services
| Service | Description | Internal Rate | External Rate* |
| EBV transformed cell line | Establishment of a lymphoblastoid cell line (LCL) by Epstein-Barr Virus (EBV) transformation of B lymphocytes isolated from a patient blood sample, creating an immortalized and renewable source of DNA and cells for long-term research use. | $130.81 | $201.45 |
| Regrow cryopreserved EBV transformed cell lines | Recovery and expansion of a previously cryopreserved EBV-transformed lymphoblastoid cell line from biorepository storage to generate a viable, actively growing culture ready for downstream use. | $126.82 | $195.30 |
| Generate fibroblasts from skin biopsy | Primary dermal fibroblast culture established from a patient skin punch biopsy. Fibroblasts serve as a renewable source of patient-derived cells and can be used as starting material for reprogramming into induced pluripotent stem cells (iPSCs) or for other cell-based assays. | $138.46 | $213.23 |
| Serum or plasma isolation | Separation and collection of serum or plasma from whole blood samples using standardized centrifugation protocols. Specimens are aliquoted and prepared for biobanking or downstream biochemical and molecular analysis. | $12.77 | $19.67 |
| PBMC isolation | Isolation of peripheral blood mononuclear cells (PBMCs), including lymphocytes and monocytes, from whole blood using density gradient centrifugation. Cells can be used fresh or cryopreserved for future use. | $51.98 | $80.06 |
| Hourly Rate | Services billed at hourly rate. For non-standard work requests, our team tracks time daily using JIRA. Hours are calculated at the end of each month and invoiced at the beginning of the following month. | $74.00 | $113.96 |
Biorepository Service
| Service | Description | Internal Rate | Internal Subsidized** | External Rate* |
| Hourly Rate for Sample Deposit, Retrieval, Shipping | Services billed at hourly rate. Labor covers staff time for intake processing, cataloging, sample retrieval, and preparation of samples for shipment. For non-standard work requests, our team tracks time daily using JIRA. Hours are calculated at the end of each month and invoiced at the beginning of the following month. | $74.00 | $113.96 | |
| 1 standard cryobox (5.25 x 5.25 x 2.13 in) stored in a -80 Freezer (Per month) | Monthly storage fee for one standard cryobox (5.25 x 5.25 x 2.13 in) held in a monitored -80°C mechanical freezer. Suitable for long-term storage of nucleic acids, plasma, serum, and other biological specimens. Tall or oversized cryoboxes are charged at twice the standard rate. | $0.87 | $1.34 | |
| 1 standard cryobox (5.25 x 5.25 x 2.13 in) stored in Liquid Nitrogen (Per month) | Monthly storage fee for one standard cryobox (5.25 x 5.25 x 2.13 in) held in liquid nitrogen vapor-phase storage. Recommended for cryopreserved cells and samples requiring ultra-low temperature conditions. Tall or oversized cryoboxes are charged at twice the standard rate. | $5.25 | $4.10 | $8.09 |
| Note: Tall or oversized cryoboxes will be charged 2x standard price |
Induced Pluripotent Stem Cell Services
| Service | Description | Internal Rate | Internal Subsidized** | External Rate |
| iPSC generation per single patient sample (6-12 distinct cell lines) Standard Characterization is included in package | The CTRC generates feeder-free induced pluripotent stem cell (iPSC) lines from patient-derived somatic cells, including peripheral blood mononuclear cells (PBMCs) and skin fibroblasts, using Sendai non-integrating reprogramming technology. Each package delivers three independent clonal lines and includes standard pluripotency characterization, mycoplasma testing, cell line authentication, and Tag-seq transcriptome analysis. iPSCs serve as a powerful research tool for disease modeling, drug discovery, and regenerative medicine applications. | $5,685.33 | $4,250.00 | $8,755.40 |
| iPSC Regrow: per cell line | Thawing and expansion of a previously cryopreserved iPSC line under feeder-free culture conditions to produce an actively growing culture ready for downstream use or long-term banking. | $141.05 | $217.22 | |
| DNA for cell line authentication per patient | Genomic DNA extraction from an iPSC line for identity verification to confirm the derived cell line matches the source patient sample. Used as part of standard quality control prior to distribution or experimental use. | $83.50 | $128.59 | |
| Immunofluorescence analysis: 3 nuclear pluripotent markers and 2 pluripotent surface markers per patient sample | Immunostaining to confirm the pluripotent identity of iPSC lines. The panel includes nuclear markers OCT4, SOX2, and NANOG, and surface markers SSEA-4 and TRA-1-60, with imaging and quantitative analysis to validate successful reprogramming. | $616.84 | $949.93 | |
| TaqMan qPCR analysis: 4 blood markers, 4 pluripotent markers, and 2 reference genes per patient sample | Quantitative PCR-based gene expression analysis to confirm silencing of somatic blood gene signatures and activation of pluripotency markers in reprogrammed iPSC lines, providing molecular evidence of successful cell fate conversion. | $614.53 | $946.38 | |
| Molecular Karyotyping per patient sample | Chromosomal integrity analysis performed using the Illumina Global Diversity Array (GDA) kit with the STEMCNV-check bioinformatic analysis pipeline. This approach detects copy number variants, deletions, insertions, and duplications that may arise during the reprogramming process, confirming genomic stability of the derived iPSC lines prior to use in downstream experiments. | $210.34 | $323.92 | |
| Mycoplasma testing | Routine quality control testing using PCR to screen iPSC cultures for mycoplasma and bacterial contamination, confirming cell line integrity and safety prior to use or distribution to investigators. | $60.38 | $92.99 | |
| STEMdiff Trilineage Differentiation Analysis per patient sample | Functional pluripotency assay using the STEMdiff Trilineage Differentiation Kit by STEMCELL Technologies. This assay evaluates the capacity of iPSC lines to differentiate into all three embryonic germ layers: ectoderm, mesoderm, and endoderm. Results confirm the developmental potential of the derived lines and are completed within one week, providing a clear and reproducible validation of pluripotency prior to downstream use. | $796.95 | $1,227.30 | |
| Cardiomyocyte Differentiation Analysis per patient sample | Directed differentiation of iPSCs into cardiomyocytes using a monolayer-based cardiac differentiation protocol originally developed by Burridge et al. (2014) and modified by Matthew Yim and Colin Maguire at the Cellular Translational Research Core, Clinical Translational Science Institute, University of Utah. This optimized protocol provides a human cellular model for cardiovascular disease research, drug screening, and toxicity testing. Differentiation efficiency is confirmed by immunofluorescence imaging using cardiac Troponin T (cTnT) as a lineage-specific marker. | |||
| One 6-well plate cardiomyocyte differentiation | Directed differentiation of iPSCs into cardiomyocytes performed in a one 6-well plate format using the CTRC monolayer-based cardiac differentiation protocol. | $439.12 | $676.24 | |
| Cardiomyocyte Imaging (CTNT marker staining) | Immunofluorescence imaging of differentiated cardiomyocytes using cardiac Troponin T (cTnT) as a lineage-specific marker to assess differentiation efficiency and confirm cardiomyocyte identity and purity. | $561.35 | $864.48 | |
| Neural Induction Analysis per patient sample | Directed differentiation of iPSCs toward a neural progenitor cell fate, providing a human cellular model for studying neurological diseases including Alzheimer's disease, Parkinson's disease, and other neurodegenerative conditions. Analysis confirms neural induction efficiency and progenitor cell formation. | $951.77 | $1,465.73 | |
| Hourly Rate | Services billed at hourly rate. For non-standard work requests, our team tracks time daily using JIRA. Hours are calculated at the end of each month and invoiced at the beginning of the following month. | $74.00 | $113.96 | |
Gene Editing Services
| Service | Description | Internal Rate | Internal Subsidized** | External Rate* |
| 24 clones per condition (48 clones total) | CRISPR clone screening package covering two editing conditions with 24 clones screened per condition (48 clones total). Includes single-cell cloning, expansion, genomic DNA extraction, and genotyping to identify correctly edited clones. | $6,606.45 | $10,173.93 | |
| 30 clones per condition (60 clones total) | Expanded CRISPR clone screening package covering two editing conditions with 30 clones screened per condition (60 clones total). Recommended for challenging loci where a larger screening pool increases the probability of recovering correctly edited lines. | $7,639.19 | $11,764.35 | |
| Insertion | Targeted insertion of a sequence of interest such as a reporter construct, epitope tag, or corrective sequence at a defined genomic locus using CRISPR/Cas9-mediated homology-directed repair (HDR). | $7,287.69 | $11,223.04 | |
| Hourly Rate | Services billed at hourly rate. For non-standard work requests, our team tracks time daily using JIRA. Hours are calculated at the end of each month and invoiced at the beginning of the following month. | $74.00 | $113.96 |
Billing
Internal monthly billing is arranged via a “work authorization form (WAF),” which utilizes a chartfield input into ProTrackS. Itemized invoices can be provided upon request. Any billing and payment questions should be directed to Sarah Ward.