Translational Innovation Pilot (TIP) Program
The Utah CTSI’s TIP program will fund translational science projects aiming to identify and overcome barriers to the performance of translational research. Addressing critical barriers will allow subsequent translational research to accelerate the time from discovery to improved human health.
Leveraging CTSA funding, the Utah Clinical & Translational Science Institute (CTSI) will award pilots through its Translational Innovation Pilot (TIP) program. In alignment with NCATS, the Utah CTSI’s TIP program will support translational science projects that focus “on understanding a scientific or operational principle underlying a step of the translational process with the goal of developing generalizable principles to accelerate translational research.”
For additional information, please contact Breanne Johnson.
Past Recipients
PI Name | PI Title | PI Dept | Pilot Title | TS Barrier | Project Abstract |
Ann Bruno | Assistant Professor | OBGYN | A pilot study of rivaroxaban transfer into human milk | Development of a process for the study of medication excretion into human milk to allow medical research to safely be performed on lactating women |
Venous thromboembolism (VTE) accounts for 9% of maternal deaths in the U.S. The risk is highest in the first two weeks postpartum. Therefore, national guidelines recommend hospitals implement a standardized approach to VTE risk assessment and thromboprophylaxis. While not currently recommended for obstetric populations, the use of direct oral anticoagulants (DOACs) may improve VTE thromboprophylaxis and help to reduce maternal mortality in the U.S. Heparin-based prophylaxis is the currently recommended pharmacologic agent based on known lack of transfer to human milk and safety profile. However, heparin-based prophylaxis requires daily or twice daily subcutaneous injection with self-administration after hospital discharge. The injections and associated discomfort and bruising, as well as self-administration, reduce medication adherence. DOACs offer an appealing alternative based on their oral administration. DOACs are widely used for treatment and prevention of VTE in non-obstetric populations. Before DOACs can be recommended for use in a postpartum population, the potential for DOAC transfer to human milk needs to be defined. Unlike other patient populations, postpartum individuals breastfeed. Understanding the potential for DOAC exposure among nursing infants is a key safety consideration. Case reports have identified the transfer of DOACs into human milk at low concentrations when administered at relatively higher therapeutic doses. Therapeutic doses of the DOAC, rivaroxaban, had the lowest transfer to human milk. The transfer of rivaroxaban into human milk when administered at a prophylactic dose (~1/3 of a therapeutic dose) has not been studied. These data could support DOAC use to prevent postpartum VTE. We are completing a single-center, observational study of 20 postpartum individuals to evaluate the excretion of rivaroxaban into human milk when administered at a prophylactic dose. Rivaroxaban concentrations from maternal blood and milk are collected to estimate the time and magnitude of transfer, as well as relative infant doses. |
Tammy Stump | Visiting Instructor | Dermatology | STARS (Sun Protection and Tanning Awareness in Rural Schools) | Development of a process to integrate a health behavior intervention within state-mandated health education curricula | Melanoma is a significant public health problem, especially in rural areas that already experience significant health disparities. Melanoma incidence and mortality are higher in rural areas when compared to urban areas, and melanoma is diagnosed at later and harder to treat stages among individuals living in rural areas. Adolescents in rural areas are at particularly high risk for skin cancer because they do not use sufficient sun protection strategies, experience high levels of UVR exposure, and are at increased risk for sunburn occurrence. Although there are evidence-based interventions targeting adolescents’ sun exposure, translational research barriers reduced the potential impact of these interventions. These barriers include limited technology resources and differences in activity patterns sun protection attitudes compared to urban students. The overarching goal of the proposed project is to develop and pilot test a sustainable intervention targeting skin cancer prevention among high school students in Utah. To address the urgent need for skin cancer prevention programs for rural adolescents, this project has the two primary aims. First, we are evaluating barriers and facilitators to impactful and sustainable implementation of sun protection intervention in rural schools, through interviews with stakeholders. We are in the process of conducting interviews with 15 school staff, parents, and activity leaders to assess key constructs drawn from the Consolidated Framework for Implementation Research (e.g., relative advantage of the program) and have begun to use these interviews to guide refinements to plans for a school-based intervention. Second, we will conduct a pilot test of a ruraladapted skin cancer prevention intervention in rural high schools, evaluating effectiveness and implementation outcomes. The program will be co-implemented by the research team and school staff, with a focus on sustainability beyond the immediate study period. Interview and survey assessments following program implementation will evaluate both the program effectiveness and implementation outcomes (e.g., feasibility). |
Anna L. Parks | Assistant Professor | Hematology | Anti-amyloid monoclonal antibodies for dementia and intracranial hemorrhage: elucidating underlying mechanisms | Development of a biomarker | Novel monoclonal antibodies targeting amyloid for Alzheimer’s disease and related dementias (ADRD) can slow the course of disease but at the expense of increased risk of intracranial hemorrhage. How to predict and prevent this complication remains unknown. Coagulation and platelet functional assays are promising candidate predictive biomarkers. In a cohort of 20 patients receiving anti-amyloid therapy, we will measure coagulation and platelet function both pre- and three months post-treatment. Using a control group for comparison, we will measure the association between functional hemostatic testing and development of intracranial hemorrhage. In doing so, we will accomplish three broader translational science goals: 1) Validate a broadly generalizable process to adapt for bleeding prediction biomarkers across disease states, 2) Address key unmet needs for research in vulnerable older adults, ADRD biomarkers and bleeding risk prediction, 3) Establish a new multidisciplinary scientific collaboration. |
Jun Yang | Professor | Neurobiology | A pilot study on gene therapy for retinal degeneration | Development of a new gene editing therapy to correct genetic mutations which can be applied to multiple inherited diseases | Inherited diseases affect up to 5.9% of the population, equivalent to 446 million people worldwide. The pathogenic mechanisms of these diseases are mostly unclear, and there are few treatments or cures. Gene replacement therapy has shown promise, but it is more applicable to diseases caused by mutations in small genes due to the AAV packaging limit of 4.7 kb. This therapy also alters the physiological expression of target genes because it uses exogenous promoters in the viral vectors. Recently, CRISPR/Cas9-based gene editing technologies have emerged, which may address these limitations by precisely correcting mutations in the gene instead of replacing the entire gene and using exogenous promoters. In this project, we tested the efficacy of a HIER strategy (Fig. 1) to correct mutations in USH2A, a significantly large gene of 15.6 kb, with the goal of developing a therapeutic approach to rescue or slow down retinal phenotypes in USH2A patients. This approach could eventually be applied to other inherited diseases caused by mutations in large genes. Our findings demonstrated that the HIER strategy can replace mutant DNA fragments with a wild-type template and that the INDEL rate at the two ends of the replaced DNA template is acceptable when in introns. However, further improvements to the HIER strategy are necessary to increase gene editing efficacy for its potential translational application. |
Hilary Coon | Professor | Psychiatry | Community Consultation on Research Use of Autopsy Blood Spots in Utah | Articulate practical guidelines and develop a template for community-informed engagement and design of a research study | This project will develop guidelines for conducting community-informed research. As a model for this development, we will explore and implement aspects of community perceptions and opinions regarding research uses of an archived resource of ~30,000 blood spots from decedents obtained from the Utah State Office of the Medical Examiner. Preliminary linking to longitudinal medical records data indicates the presence of many diagnoses among decedents in this resource, suggesting feasibility of genetic discovery across multiple areas of medical research. This study will explore optimal ways to conduct research using this resource through input from community leaders. Issues to be addressed will include risk perceptions, sample/data access, research design, limitations on sample use, and appropriate communication of results to community members. Community leaders will also help guide the development and editing of an initial proposal using the research resource that will include community-informed hypotheses, study design aspects, and return of results methods. Finally, our process of community engagement and community-informed proposal design will allow us to create more general guidelines for the implementation of community-based research. These guidelines will be disseminated, and will serve as a practical guide for designing future community-informed research studies. |
Anne Thackeray | Assistant Professor | Physical Therapy/Athletic Training | Establishing a Functional Performance Index | Establishment of a common metric for functional performance – the functional performance index (FPI) | Functional performance (e.g., walking speed, ability to climb stairs, get in and out of a chair) is paramount for social participation, irrespective of health conditions. Self-reported measures of function are important measures that provide insight into an individual’s perception of function but are often confounded by pain and self-efficacy. Functional performance provides diagnostic and prognostic information beyond the patient’s perceptions and supports our understanding of the mechanisms associated with changes in function. The significant number of functional performance measures makes it challenging to compare studies and populations. Establishing a single functional performance index to which functional performance measures can be mapped would significantly improve the translation of research across populations and settings. We used secondary data to establish a functional performance index (FPI) as a proof of concept. We then examined FPI over time alongside patient-reported measures to determine the added value of the FPI. Mapping functional performance tests to a single measurement scale is feasible but requires further development of items and item discrimination. Functional performance changes over time are distinct from self-reported physical function and precede changes in self-reported function. |
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Year of Award Investigators Investigator Departments Project Titles 2022 M. Mateo Paz Soldan, MD, PhD Neurology Novel Imaging Markers of Innate Immune Activation in Secondary Progressive Multiple Sclerosis 2022 Guillaume Horeau, PhD, DVM Emergency Medicine Validation of a novel noninvasive monitor of renal hypoxia in a pig model of hemorrhagic shock 2022 Jungkyu (Jay) Kim, PhD Mechanical Engineering A Biomimetic Cornea Chip for studying Fuchs' dystrophy 2022 Kevin Watt, MD, PhD Pediatrics Optimizing Drug Exposure in Patients Supported with Extracorporeal Membrane Oxygenation 2022 Yue Zhang, PhD Internal Medicine Biomechanical Data Analysis using Statistical Parametric Mapping Approach in the Presence of Nested Observations 2021 Rebecca Simmons, PhD, MPH OB/GYN Understanding barriers and facilitators of implementing the LNG IUD as emergency contraception in varied clinical settings: a pilot study 2021 Tuan Pham, MD Internal Medicine Inflammation in Fatty Liver Disease 2021 Anna Ibele, MD Surgery Loss to Follow Up after Bariatric Surgery: Contributors and Consequences 2021 Sunjin Park, PhD Neurobiology & Anatomy A single-step assay determining the role of disease-associated genes in neuronal activity 2021 Hediyeh Baradaran, MD Radiology & Imaging Services MRI Evaluation of Vascular Aging and Vulnerable Plaque 2020 Alexander Pastuszak, MD, PhD Surgery Genetic Basis of Peyronie's and Dupuytren's Diseases 2020 Joseph Kim, PhD Psychiatry Affect Control Functions of the Prefrontal Cortex 2020 Vikas Sharma, MD Surgery Human Amniotic Membrane as Pericardial Substitute in Cardiac Surgery Patients 2020 Sihem Boudina, PhD Nutrition & Integrative Physiology Establishing the Function of a Novel Human Genetic Mutation in PRDM16 using Patient-Derived iPSC-CMs and In Vivo Model Systems 2020 Mary Playdon, PhD, MPH, MPhil Nutrition & Integrative Physiology Feasibility and Acceptability of Time Restricted Feeding (TRF) among Native Hawaiian/Pacific Islander Women at Risk for Endometrial Cancer