Networks We Collaborate With
Collaborative Pediatric Critical Care Research Network
Brings single IRB functions for the NICHD-funded network into the Utah Data Coordinating Resource Center
Pediatric Emergency Care Applied Research Network
Brings single IRB functions for the NICHD-funded network into the Utah Data Coordinating Resource Center
Helping to End Addiction Long-Term
HEAL is an NIH-funded initiative put together to address the national opioid health crisis. The Utah DCRC serves as the Data Coordinating Resource Center in collaboration with other partners from the HEAL Pain Effectiveness Research Network (ERN).
Studies and Trials
Dexmedetomidine Opioid Sparing Effect in Mechanically Ventilated Children
This is a multicenter double-blind randomized controlled trial of fentanyl vs. fentanyl + dexmedetomidine as the initial regimen for maintenance of sedation in mechanically ventilated critically ill children. This trial will evaluate the opioid-sparing effect of dexmedetomidine when administered with fentanyl to mechanically ventilated critically ill children. Study drug or placebo will be administered with fentanyl, which will be titrated to achieve sedation scores consistent with response to light touch. Plasma samples and bedside assessments for pain, sedation, and delirium will be collected.
Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children
The objective of this study is to provide preliminary data on the safety and efficacy of using TXA in children with traumatic injuries to the head and/or torso. This study is a multicenter randomized double-blind placebo-controlled trial. Patients will be randomized to receive one of two possible doses of TXA or a placebo of normal saline solution. The study will enroll 40 children with traumatic injuries within 4 PECARN sites nationwide over 2 years. This project is funded by the National Heart, Lung, and Blood Institute (NHLBI).
Randomized Controlled Trial of Valganciclovir for Asymptomatic Cytomegalovirus Infected Hearing Impaired Infants
Cytomegalovirus (CMV) can be transmitted from mother to fetus and cause permanent hearing loss resulting in an estimated $4 billion burden on our healthcare system annually. There is an urgent need to identify the best approach for treating infected infants to enable improved hearing and developmental language outcomes. The outcomes of this project will transform current public policies on the treatment of these children.
Hydroxychloroquine for Outpatients with Confirmed COVID-19 (HCQ Trial)
This research study is designed to test possible treatments for COVID-19 and should help us better understand the virus and if HCQ might be a good treatment.
If you are interested in accessing the publicly available group of datasets, dataset summaries, and study info for UTAHONE (Understanding Treatment and Health in the Ongoing coroNa Epidemic): A Hydroxychloroquine Outpatient Study, please click here.
Endophenotypes of Persistent Post-Concussive Symptoms in Adolescents: CARE4Kids
The National Institute of Neurological Disorders and Stroke awarded a grant to the Four Corners Youth Consortium. Led by the UCLA Steve Tisch BrainSPORT Program, the project is named Concussion Assessment, Research and Education for Kids, or CARE4Kids. While symptoms from concussions normally resolve within days to weeks, ~15-30% of school-aged children experience serious morbidity (i.e., headache, fatigue, dizziness, anxiety, inattention) lasting for >1-3 months, which can significantly interfere with academic performance, social interactions, and other functional domains. The study will collect autonomic, blood-based, and imaging biomarkers and aims to develop a predictive algorithm for adolescents who may experience persistent, post-concussive symptoms to inform clinical screening, management, and future research.