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Get Started

Get started on a new research project by bouncing ideas off of colleagues, mentors, and reviewing the literature to see what has already been completed. Identify gaps in the literature that could be filled by the proposed study.

Prior to your initial meeting with an SDBC collaborator, prepare a few relevant articles or examples of existing measures/surveys from your literature review and ideas on some of the following study design aspects:

  1. Develop your research question(s) and corresponding hypotheses – See Study Design Resources below
  2. Study design – Experimental or observational? Prospective or retrospective? Survey or focus group?
  3. Inclusion/exclusion criteria
  4. Sample size availability
  5. Potential outcome and predictor variables
    1. Major outcome variable(s): For example, a primary outcome could be mortality, secondary could be complications and/or adverse events.
    2. Major predictor/grouping variable(s): For example, Cases vs. Controls, Treatment A vs. Treatment B.
    3. Potential confounders: Variables associated with both predictor and outcome variable of interest. For example, age and time since procedure.
    4. Potential effect modifiers: Variables that exhibit different associations with the outcome within different strata of a predictor variable (i.e., variables that exhibit significant interactions with your predictor variable). For example, hip fractures are more common in young males (via trauma) than young females, but elderly females have a higher risk of hip fracture (due to osteoporosis) than elderly males. Thus the relationship between sex and hip fracture is modified by age (Methods in Observational Epidemiology, Kelsey, et al second edition).

Study Design Resources

Why Do You Need a Biostatistician?

Developing Your Research Question

Observational Studies Guidelines

Experimental Study Guidelines

Study Design/Statistics Training - Lancet & BMJ



Study Quality Assessment Tools

Our Office

Williams Building
University of Utah Research Park
Williams Building, 1st floor
295 South Chipeta Way
Salt Lake City, Utah

Parking: During construction, you may park on the bottom floor of the south parking structure.


Camie Derricott
Phone: 801-587-5212
Fax: 801-581-3623

Acknowledging the SDBC

Please use the following text to acknowledge the CTSI Study Design and Biostatistics Center:

"This investigation was supported by TRIAD, with funding in part from the National Center for Advancing Translational Sciences of the National Institutes of Health under Award Number UL1TR002538. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health."